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. 2022 Feb 1;11(2):192. doi: 10.3390/antibiotics11020192

Figure 2.

Figure 2

Time–kill assay. The reference strain K279a (A) and Sm 538 (C) were incubated with 0 mg/L, 4 mg/L, and 8 mg/L gepotidacin. The strain Sm 290 (B) was incubated with 0 mg/L, 1 mg/L, and 2 mg/L gepotidacin, while the strain Sm 1222 (D) was incubated with 0 mg/L, 2 mg/L, and 4 mg/L gepotidacin. CFU/mL were determined hourly over the first eight hours and after 24 h. Observed growth after incubation without gepotidacin (blue), with one-fold MIC (orange) and two-fold (grey) gepotidacin. Significance levels are shown by asterisks: ***: p < 0.001 and determined via two-way ANOVA using GraphPad Prism.