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. 2022 Jan 26;11(2):194. doi: 10.3390/biology11020194

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Preoperative SRS irradiates less healthy brain and kills less lymphocytes compared to Postoperative RT. (A) Preoperative (left) and postoperative (right) MRI showing preoperative SRS PTV (red) as compared to standard postoperative RT PTV (blue). As demonstrated, the vast majority of tissue irradiated during preoperative SRS is resected and minimal dose of radiation is delivered by SRS beyond the tumor bulk. (B) Changes in serum naive CD8+ lymphocytes after SRS compared to postoperative RT based on our preliminary mathematical modeling. Staggered edge reflects weekend recovery.