Table 2.

Evidence of the effects of Nrf2 inducers in rodent models of diabetic neuropathy (DN).

Nrf2 Inducer	Animals (Sex, Strain)	Dose (mg/kg) and Administration Route	Mechanism of Action	Reference
Resveratrol	Nrf2−/− and Nrf2+/+ CD1/ICR mice	10 mL/kg 10%, intragastric	Nrf2 pathway	[67]
Polydatin	Male Sprague Dawley rats	25 and 50 mg/kg, oral 10, 20 µM in neuro2a—mouse neuroblastoma cells—in vitro	SIRT1/Nrf2 pathway	[74]
Oltipraz	Rat Schwann cell line	20 µM on RSC96 cells—Schwann cell line—in vitro	Nrf2/NQO1 pathway	[73]
Bardoxolone methyl	Male Sprague Dawley rats	15 and 30 mg/kg/day, oral	keap1-Nrf2-ARE pathway	[72]
Diosgenin	Male C57 mice	50 and 100 mg/kg, intragastric	Nrf2/HO-1 pathway	[63]
Bergenin	Male C57BL/6 mice	3.125–25 mg/kg, i.p.	Nrf2 pathway	[62]
Diphenyl diselenide	Male Sprague Dawley rats	5 and 15 mg/kg, oral	Nrf2/Keap1 pathway	[70]
Deguelin	Male Sprague Dawley rats	4, 6, and 8 mg/kg, oral gavage	Nrf2 pathway	[64]
Tanshinone IIA	Male Sprague Dawley rats	25 mg/kg, i.p.	Nrf2/ARE pathway	[71]
Rutin	Male Wistar rats	Rutin—100 and 200 mg/kg, i.p. Nimesulid—5 and 10 mg/kg, i.p. Combination—200 mg/kg rutin + 10 mg/kg nimesulid, i.p.	Nrf2/HO-1/NF-κB and COX pathway	[79]
Sulforaphane	BKS.Cg-m+/+Leprdb/J and db/db mice	Sulforaphane—2.5, 5, and 10 mg/kg, s.c. DPDPE and SNC-80—0.15, 0.5, 1, and 5 mg/ kg, s.c. Combination—10 mg/kg, i.p. sulforaphane alone or 10 mg/kg, i.p. sulforaphane + 0.15 mg/kg, s.c DPDPE, 10 mg/kg, i.p. sulforaphane + 0.5 mg/kg, s.c. SNC-80	Nrf-2/HO-1 pathway	[81]
Quercetin	Sprague Dawley rats’ embryos	10 mmol/L quercetin, 1 IU/mL hirudin, 100 nmol/L cinnamaldehyde on DRG neurons from 15d embryos of Sprague Dawley rats—in vitro Combination—quercetin + hirudin, quercetin + cinnamaldehyde, cinnamaldehyde + hirudin, quercetin + cinnamaldehyde + hirudin	Nrf-2/HO-1 pathway	[80]
Tangluoning	Male Sprague Dawley rats	10.9 g and 21.8 g crude drug/kg/day, intragastric	PERK/Nrf2 pathway	[55]
Isoliquiritigenin	Male Sprague Dawley rats	10 and 20 mg/kg, oral 2.5 and 5 µM on neuro2a—mouse neuroblastoma cells—in vitro	SIRT1/Nrf2 pathway	[78]
Anomalin	Male ICR mice	50 mg/kg, i.p. 50 µM on DRG primary cells, N2a—mouse neuroblastoma cell line	Nrf2 pathway	[66]
Fisetin	Male Sprague Dawley rats	5 and 10 mg/kg, oral	Nrf2 pathway	[65]
Rutin	Male Sprague Dawley rats	5, 25, and 50 mg/kg, i.p.	Nrf2 pathway	[68]
Paeoniflorin	Rat Schwann cell line	1, 10, and 100 µM in RSC96 cells—Schwann cell line—in vitro	Nrf2/ARE pathway	[61]
Taurine	Male Wistar rats	2% w/v, oral	Nrf2/HO-1 pathway	[69]

Note. Table is organized based on the most recent to oldest publications.