Table 5.

Evidence of the effects of Nrf2 inducers in rodent models of sciatic nerve crush (SNC), partial sciatic nerve ligation (PSNL), spared nerve injury (SNI), and spinal nerve ligation (SNL).

Nrf2 Inducer	Animals (Sex, Strain)	Dose (mg/kg), Route of Administration	Mechanism of Action	Reference
Sciatic nerve crush (SNC) injury
Isoquercitrin	Male ICR mice	20 mg/kg/day, i.p. 40 to 320 μM isoquercitrin on primary Schwann cells isolated from sciatic nerves of neonatal 1-day-old Sprague Dawley rats—in vitro	Nrf2 pathway	[139]
Curcumin	Male Sprague Dawley rats	0.2 mg/day, continuous delivery through mini-osmotic pumps	Nrf2 pathway	[140]
Sesame oil	Male SPF C57BL/6 mice	0.5, 1 and 2 mL/kg, oral	Nrf2 pathway	[141]
Partial sciatic nerve ligation (PSNL)
ECN	Male albino mice	1 and 5 mg/kg, i.p.	Nrf2/HO-1/NQO1 pathway	[142]
Spared nerve injury (SNI)
tBHQ	Male Sprague Dawley rats	1 and 10 μM, i.t.	Nrf2 pathway	[143]
Dimethyl fumarate	Male Sprague Dawley rats and male and female wild type and Nfe2l2−/− mice	30, 100, and 300 5 mL−1 kg−1, oral	Nrf2 pathway	[144]
Sulforaphane	Male Sprague Dawley rats	30 mg/kg, i.p.	Keap1-Nrf2 signaling	[145]
Spinal nerve ligation (SNL)
Dimethylitaconate	Male C57BL/6 mice	10 mg or 20 mg, i.p. 250 µM on BV2 microglial cell line	Nrf2 pathway	[146]

Note. Table is organized based on the most recent to oldest publications.