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. 2022 Feb 13;11(2):303. doi: 10.3390/biology11020303

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Photomicrograph of colons of different groups stained with H&E stain. (A) NC group showing a normal histological finding of the colon. (B) UC group showing area of ulcerative colitis with complete destruction of the colon mucosa. (C) UC group showing complete crypt necrosis, inflammatory cell infiltration in the mucosa and submucosa and congestion of blood vessels. (D) UC group showing complete necrosis of the mucosa with submucosal fibrous connective tissue proliferation with mononuclear inflammatory cell aggregation. (E) MIC-20 showing necrosis of some crypts with a moderate inflammatory reaction in the mucosa and submucosa. (F) MIC-40, (G) SSZ-100 and (H) MIC + SSZ groups showing minimal inflammatory reaction in the mucosa and submucosal edema.