Table 3.
Expression of previously identified molecular targets involved in chronic liver disease with a Fisher’s p-value of <0.01.
| Gene | Gene Name | Function | Main Associated Pathways | Nb Comparison Up | Nb Comparison Down | Median logFC | Fisher’s p-Value |
|---|---|---|---|---|---|---|---|
| Pparg | Peroxisome proliferator-activated receptor gamma | Nuclear receptor involved in critical metabolism regulations of various cell types, notably adipocyte differentiation. | MAPK-Erk | 0 | 3 | 0.268 | 1.8 × 10−3 |
| Tlr2 | Toll-like receptor 2 | Membrane surface receptor essential for pathogen recognition and innate immune response activation. | NF-kappa-B; MAPK-Erk | 0 | 2 | 0.135 | 3.3 × 10−2 |
| Fgf21 | Fibroblast growth factor 21 | Hepatokine involved in mitogenic activities. Major regulator of energy homeostasis. | MAPK-Erk; Insulin signaling | 2 | 0 | 0.131 | 0.079 |
| Fgfr1 | Fibroblast growth factor receptor 1 | Receptor tyrosine kinase that plays a fundamental role in embryogenesis and cell development. | MAPK-Erk; PI3K/AKT | 0 | 1 | 0.064 | 0.092 |
Abbreviations: Nb comparison up: Number of gene enrichment sets in which the gene is upregulated; Nb comparison down: Number of gene enrichment sets in which the gene is downregulated; LogFC: log2 fold change.