Table 1.
Diterpenoids isolated from plants with their IC50 values of cholinesterase inhibitory activities.
| Species | Plant Parts | Extraction Method | Types of Compound | Chemical Constituent | Cholinesterase Inhibition (µM) (A: AChE, B: BuChE) |
References |
|---|---|---|---|---|---|---|
| Caryopteris mongolica | Aerial part | Extract with acetone water (4:1), quenched with diethyl ether and water, diethyl ether fraction was passed through HP20 column | Abietane diterpenoid | 12-O-demethylcryptojaponol (7) | 50.8 (A) 70.1 (B) |
[14] |
| 6α-hydroxydemethylcryptojaponol (8) | 12.3 (A) 7.7 (B) |
|||||
|
Lycopodiastrum
casuarinoides |
Aerial part | Extract with 75% ethanol, partitioned with EtOAc and 3% tartaric acid, column chromatography | Abietane diterpenoid | Lycocasuarinone A (9) | 26.8 (A) | [15] |
|
Perovskia atriplicifolia
Salvia glutinosa |
Root | Sonicate with hexane, column chromatography | Nor-abietanoid | Arucadiol (10) | 4.0 (B) | [22] |
| Miltirone (11) | 0.90 μg/mL (B) | |||||
| Tanshinone IIa (12) | 2.79 μg/mL (B) | |||||
| 1-oksomiltirone (13) | 5.06 μg/mL (B) | |||||
| Cryptotanshinone (14) | 1.15 μg/mL (B) | |||||
| 1,2-didehydromiltirone (15) | 1.12 μg/mL (B) | |||||
| 1,2-didehydrotanshinone IIa (16) | 5.98 μg/mL (B) | |||||
| 1β-OH-cryptotanshinone (17) | 1.21 μg/mL (B) | |||||
| 15,16-dihydrotanshinone (18) | 1.71 μg/mL (B) | |||||
| Tanshinone I (19) | 11.24 μg/mL (B) | |||||
| Isotanshinone II (20) | 9.16 μg/mL (B) | |||||
| 1(S)-OH-tanshinone IIa (21) | 5.71 μg/mL (B) |