Table 1.
α-glucosidase, PTP1B, AGEs, and peroxynitrite inhibitory activities of MeOH extract of Morus alba branch and its fractions.
| Fractions | IC50 Values (μg/mL) 1 | |||
|---|---|---|---|---|
| α-Glucosidase | PTP1B | AGEs | ONOO− | |
| MeOH ext. | 100.3 ± 0.55 | 55.29 ± 27.46 | 23.06 ± 0.84 | 12.01 ± 1.43 |
| CH2Cl2 fr. | 135.3 ± 0.69 | 12.86 ± 2.45 | 48.64 ± 6.38 | 14.63 ± 0.92 |
| EtOAc fr. | 2.74 ± 0.15 | 8.09 ± 0.08 | 6.40 ± 0.31 | 6.74 ± 0.15 |
| n-BuOH fr. | 241.7 ± 0.10 | 15.05 ± 1.57 | 36.65 ± 2.00 | 10.98 ± 0.46 |
| H2O fr. | 457.9 ± 0.98 | >100 | >100 | 22.11 ± 3.56 |
| Acarbose 2 | 494.1 ± 1.19 | - | - | - |
| Ursolic acid 2 | - | 4.56 ± 0.22 | - | - |
| Aminoguanidine 2 | - | - | 52.62 ± 6.70 | - |
| l-Penicillamine 2 | - | - | - | 1.37 ± 0.19 |
1 The 50% inhibition concentration (IC50) is expressed as the mean ± SD of triplicate experiments. 2 Positive controls used in the assays.