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. 2022 Feb 13;12(2):305. doi: 10.3390/biom12020305

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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WTp53-driven secretome inhibits cancer cell migration. Wound closure cell assay on the confluent p53-null AsPC-1 cell monolayer cultivated with WTp53-derived conditioned medium (CM) as compared to CM derived from its mock control. A scratch was performed in the cell monolayer at time zero, after that we monitored cell migration for 48 h. The images were analyzed quantitatively by using ImageJ computing software. Migration ability expressed as relative migration distance (RMD) decreased in cells cultured with WTp53-derived CM. Statistical analysis *p < 0.05 CM-WTp53 vs. CM-Mock. Scale bar: 500 µm.