Table 2.
Statistical analysis of mRNA expression of genes involved in immunity and tryptophan metabolism in gastric cancers. Median (range) of gene mRNA expression levels GCs as compared to non tumoral gastric tissue (PT normalized to 1); p value a (Mann Whitney’s U test); Significant p-value a < 0.05 (in bold); median range of genes between GC subtypes, p value (Mann Withney pliciter le test). Significant p-value < 0.05 (in bold). NS, not significant. Comparative basal levels of genes in normal tissue (x1) are as follow: PD1 (19), PDL1 (53), PDL2 (86), IDO1 (70), TDO2 (18) and IDO2 (1).
| Genes | PT (n = 11) | All Tumors (n = 29) | p-Value a | Intestinal-GC vs. PT (n = 16) |
p-Value a | Diffuse-GC vs. PT (n = 13) |
p-Value a | p-Value subtypes |
|---|---|---|---|---|---|---|---|---|
| Immunity | ||||||||
| PD/PDCD1 | 1 (0.35–2.80) | 1.63 (0.81–5.3) | 0.001 | 1.71 (0.81–5.30) | 0.003 | 1.53 (0.87–3.08) | 0.009 | 0.35 (NS) |
| PDL1/CD274 | 1 (0.57–2.70) | 1.27 (0.52–6.63) | 0.33 (NS) | 1.46 (0.52–6.63) | 0.08 (NS) | 1.03 (0.57–1.56) | 0.84 (NS) | 0.018 |
| PDL2/PDCDL2 | 1 (0.54–1.63) | 1.52 (0.7–2.84) | 0.009 | 1.67 (0.70–2.79) | 0.014 | 1.21 (0.89–2.84) | 0.036 | 0.51 (NS) |
| Trypt metabolism | ||||||||
| IDO1 | 1 (0.19–1.46) | 2.17 (0.34–205) | <0.0001 | 3 (0.34–205) | 0.0006 | 1.96 (0.57–4.78) | 0.002 | 0.14 (NS) |
| TDO2 | 1 (0.45–2.95) | 5.41 (1.36–25.2) | <0.0001 | 7.45 (1.4–25.2) | <0.0001 | 3.33 (1.36–11.9) | 0.0002 | 0.049 |
| Arylhydrocarbon receptor | ||||||||
| AhR | 1 (0.37–1.64) | 1.94 (0.55–3.53) | 0.002 | 1.60 (0.65–3.53) | 0.003 | 2.12 (0.55–3.35) | 0.001 | 0.13 (NS) |