Table 3.
Correlation of genes involved in immune checkpoints (PD1, PD-L1 and PD-L2) with clinical parameters in all gastric tumors and subtypes. Median (range) of gene mRNA expression levels; p value (Mann Whitney). * Significant p value < 0.05 (in bold). ND, not determined, EPN, perineural invasion, TNM, tumor, node, metastasis.
| All Gastric Tumors (n = 29) | Intestinal Sub-Type (n = 16) | Diffuse Sub-Type (n = 13) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| PD1 | PDL1 | PDL2 | PD1 | PDL1 | PDL2 | PD1 | PDL1 | PDL2 | |||
| Gender. | p = 0.25 | p = 0.51 | p = 0.65 | Gender. | p = 0.11 | p = 0.58 | p = 0.15 | Gender. | p = 0.81 | p = 0.80 | p = 0.19 |
| Male (n = 13) | 1.5 (0.8–3.1) | 1.14 (0.5–6.6) | 1.21 (0.7–2.8) | Male (n = 7) | 1.5 (0.81–3.13) | 1.4 (0.52–6.63) | 1.17 (0.7–2.65) | Male (n = 6) | 1.51 (0.87–3.08) | 1.04 (0.62–1.27) | 1.71 (0.89–2.84) |
| Female (n = 16) | 1.7 (1.2–5.3) | 1.33 (0.6–5.5) | 1.53 (0.9–2.8) | Female (n = 9) | 2.18 (1.42–5.3) | 2.03 (0.78–5.55) | 1.83 (1.12–2.8) | Female (n = 7) | 1.58 (1.22–2.01) | 1.03 (0.57–1.56) | 1.16 (0.89–1.83) |
| Age | p = 0.08 | p = 0.18 | p = 0.20 | Age | ND | ND | ND | Age | p = 0.72 | p = 0.12 | p = 0.80 |
| <60 years (n = 9) | 1.49 (0.8–2.0) | 1.09 (0.5–1.6) | 1.21 (0.8–1.8) | <60 years (n = 1) | 0.81 | 0.52 | 0.76 | <60 years (n = 8) | 1.51 (0.87–2.01) | 1.11 (0.62–1.56) | 1.38 (0.89–1.83) |
| >60 years (n = 20) | 1.71 (0.9–5.3) | 1.33 (0.6–6.6) | 1.67 (0.7–2.8) | >60 years (n = 15) | 1.76 (0.94–5.3) | 1.52 (0.8–6.63) | 1.83 (0.7–2.8) | >60 years (n = 5) | 1.58 (1.22–3.08) | 0.78 (0.57–1.27) | 1.16 (0.90–2.84) |
| Tumor invasion | p = 0.74 | p = 0.72 | p = 0.32 | Tumor invasion | p = 0.86 | p > 0.9999 | p > 0.9999 | Tumor invasion | ND | ND | ND |
| T1-T2 (n = 6) | 1.42 (1–5.3) | 1.14 (0.6–85) | 0.93 (0.7–2.8) | T1-T2 (n = 4) | 2.85 (0.94–5.3) | 1.67 (0.96–4.25) | 1.66 (0.7–2.8) | T1-T2 (n = 2) | 1.42 (1.27–1.58) | 0.67 (0.57–0.78) | 0.93 (0.9–0.96) |
| T3-T4 (n = 23) | 1.65 (0.8–3.1) | 1.27 (0.5–6.6) | 1.55 (0.8–2.8) | T3-T4 (n = 12) | 1.71 (0.81–3.13) | 1.46 (0.52–6.63) | 1.67 (0.76–2.65) | T3-T4 (n = 11) | 1.53 (0.9–3.1) | 1.1 (0.62–1.56) | 1.55 (0.89–2.84) |
| Vascular invasion | p = 0.23 | p = 0.48 | p = 0.04 * | Vascular invasion | p = 0.14 | p = 0.56 | p = 0.03 * | Vascular invasion | p > 0.9999 | p = 0.83 | p = 0.79 |
| negative (n = 9) | 1.63 (1.3–5.3) | 1.56 (0.6–6.6) | 1.83 (1.2–2.8) | negative (n = 6) | 2.66 (1.42–5.3) | 3.07 (0.78–6.63) | 2.16 (1.21–2.8) | negative (n = 3) | 1.53 (1.32–1.63) | 0.88 (0.62–1.56) | 1.21 (1.18–1.72) |
| positive (n = 20) | 1.61 (3.1–5.3) | 1.22 (0.5–5.5) | 1.17 (0.7–2.8) | positive (n = 10) | 1.65 (0.81–2.5) | 1.37 (0.52–5.55) | 1.17 (0.7–2.65) | positive (n = 10) | 1.53 (0.87–3.08) | 1.06 (0.57–1.35) | 1.35 (0.89–2.84) |
| Lymphatic invasion | p = 0.05 | p = 0.009 * | p = 0.72 | Lymphatic invasion | p = 0.054 | p = 0.04 * | p = 0.39 | Lymphatic invasion | ND | ND | ND |
| negative (n = 11) | 2.18 (0.9–3.1) | 2.03 (0.6–6.6) | 1.21 (0.7–2.8) | negative (n = 10) | 2.24 (0.94–5.3) | 3.07 (0.96–6.63) | 1.36 (0.7–2.8) | negative (n = 1) | 1.53 | 0.62 | 1.18 |
| positive (n = 17) | 1.49 (0.8–3.1) | 1.03 (0.5–1.6) | 1.71 (0.8–2.9) | positive (n = 5) | 1.48 (0.81–1.66) | 0.87 (0.52–1.52) | 2.22 (0.76–2.65) | positive (n = 12) | 1.53 (0.87–3.08) | 1.06 (0.57–1.56) | 1.38 (0.89–2.84) |
| Metastasis | p = 0.25 | p = 0.15 | p = 0.20 | Metastasis | ND | ND | ND | Metastasis | p = 0.93 | p = 0.82 | p = 0.79 |
| negative (n = 24) | 1.65 (0.9–5.3) | 1.29 (0.6–6.6) | 1.71 (0.7–2.8) | negative (n = 15) | 1.76 (0.94–5.3) | 1.52 (0.8–6.63) | 1.83 (0.7–2.8) | negative (n = 9) | 1.49 (0.87–3.08) | 1.03 (0.57–1.32) | 1.71 (0.89–2.84) |
| positive (n = 5) | 1.53 (0.8–2) | 0.72 (0.5–1.6) | 1.18 (0.8–1.5) | positive (n = 1) | 0.81 | 0.52 | 0.76 | positive (n = 4) | 1.58 (1.22–2.01) | 1.03 (0.62–1.56) | 1.19 (1.16–1.55) |
| TNM | p = 0.37 | p = 0.008 * | p = 0.43 | TNM | p = 0.037 * | p = 0.03 * | p = 0.33 | TNM | p = 0.21 | p = 0.52 | p = 0.80 |
| I-II (n = 16) | 1.8 (0.9–5.3) | 1.33 (0.9–6.6) | 1.36 (0.7–2.8) | I-II (n = 11) | 2.18 (0.94–5.3) | 2.03 (0.96–6.63) | 1.21 (0.7–2.8) | I-II (n = 5) | 1.32 (0.87–1.9) | 1.09 (0.88–1.32) | 1.71 (0.89–1.83) |
| III-IV (n = 13) | 1.53 (0.8–3.1) | 0.87 (0.5–1.6) | 1.55 (0.76–2.8) | III-IV (n = 5) | 1.48 (0.81–1.66) | 0.87 (0.52–1.52) | 2.22 (0.76–2.65) | III-IV (n = 8) | 1.6 (1.22–3.08) | 0.88 (0.57–1.56) | 1.19 (0.9–2.84) |
| EPN | p = 0.13 | p > 0.999 | p = 0.54 | EPN | p = 0.02 * | p = 0.86 | p = 0.11 | EPN | ND | ND | ND |
| negative (n = 6) | 2.1 (1.3–5.3) | 1.26 (0.6–4.25) | 1.67 (0.9–2.8) | negative (n = 4) | 3.5 (1.76–5.3) | 1.69 (1.18–4.25) | 2.16 (1.52–2.8) | negative (n = 2) | 1.42 (1.27–1.58) | 0.67 (0.57–0.78) | 0.93 (0.9–0.96) |
| positive (n = 23) | 1.53 (0.8–3.1) | 1.29 (0.5–6.6) | 1.21 (0.7–2.8) | positive (n= 12) | 1.57 (0.81–3.13) | 1.46 (0.52–6.63) | 1.19 (0.7–2.65) | positive (n = 11) | 1.53 (0.9–3.1) | 1.1 (0.62–1.56) | 1.55 (0.89–2.84) |
| Smoking | p = 0.75 | p = 0.91 | p = 0.0006 * | Smoking | p = 0.45 | p = 0.46 | p = 0.0003 * | Smoking | p = 0.63 | p = 0.57 | p = 0.74 |
| negative (n = 12) | 1.58 (0.9–5.3) | 1.26 (0.6–4.2) | 1.83 (0.9–2.6) | negative (n = 8) | 1.71 (1.42–5.3) | 1.37 (0.78–4.25) | 2.05 (1.52–2.65) | negative (n = 4) | 1.51 (0.87–1.63) | 1.11 (0.62–1.56) | 1.19 (0.89–1.71) |
| positive (n = 10) | 1.61 (0.8–3.1) | 1.33 (0.5–6.6) | 1.04 (0.7–1.5) | positive (n = 7) | 1.65 (0.81–3.13) | 1.54 (0.52–6.63) | 1.12 (0.7–1.21) | positive (n = 3) | 1.58 (1.27–2.01) | 0.78 (0.57–1.35) | 0.96 (0.9–1.55) |