ADT	Androgen deprivation therapy
AF-1	Activation function-1
APC	Adenomatous polyposis coli
AR	Androgen receptor
AREs	Androgen response elements
AXIN1/2	Axis inhibitior 1/2
β-TrCP	Beta-transducin repeat containing E3 ubiquitin protein ligase
BCL9	B-cell lymphoma 9
BRCA1/2	Breast cancer gene 1/2
CAM	Chick chorioallantoic membrane
CBP	CREB binding protein
CCND1	Cyclin D1
cfDNA	Cell-free DNA
CK1α	Casein kinase 1α
CK1δ/ε	Casein kinase 1 delta/epsilon
CKAP4	Cytoskeleton-associated protein 4
CRC	Colorectal cancer
CRD	Cysteine-rich domain
CRPC	Castration-resistant prostate cancer
CTCs	Circulating tumor cells
CTNNB1	Catenin Beta 1
DAG	1,2 diacylglycerol
DHT	Dihydrotestosterone
DKK	Dickkopf
DVL	Disheveled
ELISA	Enzyme-linked immunosorbent assay
EMT	Epithelial-to-mesenchymal transition
FZD	Frizzled
FACS	Fluorescence-activated cell sorting
FAP	Familial adenomatous polyposis coli
GEMMs	Genetically engineered mouse models
GPCRs	G-protein coupled receptors
GR	Glucocorticoid receptor
GSEA	Gene set enrichment analysis
GSK3β	Glycogen synthase-3 beta
H3K4me	Methylated histone H3, lysine 4
HCC	Hepatocellular carcinoma
HG-PIN	High-grade prostate intraepithelial neoplasia
HR	Hazard ratio
IGF1R	Insulin-like growth factor 1 receptor
IHC	Immunohistochemistry
IP3	Inositol 1,4,5-triphosphate
JNK	Jun-N-terminal kinase
KAI1	Kangai 1 (CD82)
LATS2	Large tumor suppressor kinase 2
LBD	Ligand-binding domain
LG-PIN	Low-grade prostate intraepithelial neoplasia
LGR4/5/6	Leucine rich repeat containing G protein-coupled receptor 4/5/6
LRP5/6	Low-density lipoprotein receptor-5/6
LZTS2	Leucine zipper tumor suppressor 2
mAb	Monoclonal antibody
MAPK	Mitogen-activated protein kinase
MCL	Mantle cell lymphoma
mCRPC	Metastatic castration resistant prostate cancer
mHSPC	Metastatic hormone sensitive prostate cancer
MET	Mesenchymal-to-epithelial transition
MMP2	Matrix metalloproteinase-2
MYC	MYC Proto-Oncogene, BHLH Transcription Factor
NEPC	Neuroendocrine prostate cancer
NFAT	Nuclear factor of activated T-cells
NF-κB	Nuclear factor kappa B
NK	Natural killer
NSCLC	Non-small cell lung cancer
OS	Overall survival
PARP	Poly(ADP-ribose) polymerase
PARylation	Poly(ADP-ribosyl)ation
PCP	Planar cell polarity
PDO	Patient-derived organoid
PDX	Patient-derived xenograft
PDX-Os	Patient-derived xenograft organoids
PI3K	Phosphoinositide 3-kinase
PIN	Prostate intraepithelial neoplasia
PKC	Protein kinase C
PLC	Phospholipase C
polyQ	Polyglutamine
PONTIN	RuvB-Like AAA ATPase 1, RUVBL1
PR	Progesterone receptor
PSA	Prostate specific antigen
PTEN	Phosphatase and tensin homologue deleted on chromosome 10
PYGO1/2	Pygopus Family PHD Finger
RAC	Rac Family Small GTPase
RAS	Rat sarcoma virus
REIC	Reduced expression in immortalized cells
REPTIN	RuvB-Like AAA ATPase 2, RUVBL2
RhoA	Ras homolog family member A
RNF43	Ring finger protein 43
ROR2	Receptor tyrosine kinase-like orphan receptor 2
ROCK1	Rho associated protein kinase
R-SPO	R-Spondin
RYK	Receptor tyrosine kinase
sFRPs	Secreted frizzled-related proteins
SNAI2	Snail family transcriptional repressor 2
SOST	Sclerostin
TGFB2	TGFβ type II receptor
TCF/LEF	T-cell factor/lymphoid enhancer factor
Tip60	Lysine acetyltransferase 5, KAT5
TMPRSS2-ERG	Transmembrane serine protease 2–erythroblast transformation specific (ETS) Transcription Factor ERG fusion protein
TNBC	Triple-negative breast cancer
t-NEPC	Treatment-induced neuroendocrine prostate cancer
UGS	Urogenital sinus
VANGL1/2	Van gogh-like protein 1/2
WIF1	Wnt inhibitory factor 1
WLS	Wntless
YAP	Yes-associated protein
ZNRF3	Zinc and ring finger 3