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. 2022 Jan 21;10(2):230. doi: 10.3390/biomedicines10020230

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Complement, but not perforin, deficiency limits the vaccine-induced anti-Her2 antibody response. (A) Anti-Her2 total IgG titers after two (left panel) and three (right panel) pVAX or RHuT vaccination courses in BALB/c (black bars; n = 14), BALB-pfpKO (grey bars; n = 7), BALB-C1KO (light blue bars; n = 6), and BALB-C3KO (blue bars; n = 9) mice. Data are expressed as means ± SEM of the mean fluorescence intensity (MFI) of each serum. ns, not statistically significant; * p = 0.04; *** p = 0.0002, Student’s t-test. (B) Percentage of anti-Her2 IgG isotypes in the sera of RHuT vaccinated BALB/c, BALB-pfpKO, BALB-C1KO, and BALB-C3KO mice.