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. 2022 Feb 18;12(2):328. doi: 10.3390/biom12020328

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Increased RasGRP1 mRNA levels in the DLPFC of patients with SCZ. Expression levels of (a) RasGRP1 mRNA in the post-mortem DLPFC of SCZ patients (SCZ) (n = 18) and control subjects (CTRL) (n = 19). Quantification of western blot analysis of (b) RasGRP1 protein levels in the total homogenates of post-mortem DLPFC of SCZ-affected patients (SCZ) (n = 20) and control subjects (CTRL) (n = 19). The variations of RasGRP1 protein levels in patients affected by SCZ are expressed as percentage (%) of the control subjects. All markers were normalized to GAPDH for variation in loading and transfer; (c) representative images of immunoblots of RasGRP1 performed in the DLPFC of SCZ patients and control subjects. Each dot represents value from a single subject. * p < 0.05 compared to control group (Unpaired t-test). Multivariable regression analysis was performed against age and post-mortem interval (PMI).