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. 2022 Jan 29;10(2):320. doi: 10.3390/biomedicines10020320

Figure 6.

Figure 6

Effects of zingerone NPs on MMPs activity of human OSCC cell lines. Cells were incubated in serum-free DMEM and contained with various doses of zingerone and/or zingerone NPs for 24 h. The conditioned media of (A) Ca9-22 cells, (B) Ca1-27 cells, and (C) SAS cells were collected to analyze MMP activity, including MMP2 and MMP9, using a gelatin zymography assay. Moreover, the mRNA expression levels of MMP2 in (D) Ca9-22 cells, (E) Ca1-27 cells, and (F) SAS cells were analyzed using qPCR analysis. Data are mean ± SEM of three independent experiments. * p < 0.05, ** p < 0.01.