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. 2022 Jan 27;10(2):292. doi: 10.3390/biomedicines10020292

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) In the Ivy Glioblastoma Atlas Project dataset, RSI was compared between anatomic MES in the tumor microenvironment. p-values, estimated by one-way analysis of variance (ANOVA), are shown in the graph. (B) Heatmap representing immune cells deconvoluted by the CIBERSORTx algorithm and RSI according to anatomic MES. (C) Scatter plots showing RSI and M1/M2 macrophage ratio according to anatomic MES. Fitted line (sold) and its 95% CI error (dotted) is shown in each plot. (D) In a single-cell RNA sequencing dataset (GSE84465), mean RSI with 95% CI are estimated from collection of single cells in each study patient. p-value was estimated by ANOVA. In the right panel, pie charts are demonstrated with respect to proportion of macrophages. Abbreviations: CI, confidence interval; M1, M1 macrophage; M2, M2 macrophage; RSI, radiosensitive index; MES, microenvironment structures.