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. 2022 Feb 18;12(2):53. doi: 10.3390/bs12020053

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dams with a hypertensive disorder of pregnancy (HDP) have anxiety and delays in learning. PreE rats spent significantly more time in the open arms of the elevated plus maze, a behavior which was not corrected by Orencia infusion (A). There were no significant differences between groups observed in the discrimination index for novel object recognition (B). When Barnes maze was assessed over 5 days, only on day 4 were significant differences observed (C). However, there was an overall increase in latency to reach the goal box among HDP rats. There was no statistical change in memory due to Orencia administration (D). Data were analyzed by two-way ANOVA followed by Tukey’s post hoc test and presented as mean ± SEM (n = 11–13/group). *–** denotes p < 0.05–p < 0.005 in comparison to the indicated group. Abbreviations: NP (normal pregnant); PreE (preeclampsia); HELLP (hemolysis elevated liver enzyme low platelet).