Figure 5.

Circulating levels of S100B and BDNF are altered in response to HDP. PreE rats had increased levels of S100B (A), and HDP rats had decreased levels of circulating BDNF (B) compared to NP rats. Circulating levels of S100B are positively correlated with immobility time in the forced swim test (FST, (C)) and negatively correlated with the percent of sucrose consumed (D) and time spent in the open arms of the elevated zero maze (EZM, (E)), whereas circulating BDNF levels are negatively correlated with the time spent in the outer zones of the open field (OF, (F)). On figures (C–F), the lines represent linear regression, and the circles represent experimental animals. Data were analyzed by two-way ANOVA followed by Tukey’s post hoc test and presented as mean ± SEM (n = 5–8/group), and the correlations were determined via Pearson correlation. *–** denotes p < 0.05–p < 0.005 in comparison to the indicated group. Abbreviations: NP (normal pregnant); PreE (preeclampsia); HELLP (hemolysis elevated liver enzyme low platelet).