Table 1.
Birth outcomes and mean arterial pressure for dams in the current study. Birth outcomes were collected on post-partum day 0, which was marked by the delivery of rat pups. Mean arterial pressure was collected at the end of the study at post-partum week 9.
| Variables | NP | PreE | HELLP | NP + O | PreE + O | HELLP + O | p Value 1 |
|---|---|---|---|---|---|---|---|
| Pup Birth Wt (g) | 7.05 ± 0.03 | 7.1 ± 0.2 | 6.7 ± 0.2. | 6.7 ± 0.2 | 7.1 ± 0.2 | 7.2 ± 0.2 | 0.62 |
| Litter # | 9.7 ± 1 | 9.8 ± 0.8 | 9.5 ± 0.9 | 10.8 ± 0.7 | 8.7 ± 0.8 | 10.3 ± 1.3 | 0.53 |
| MAP (mmHg) | 111.3 ± 3.9 a | 116 ± 3.6 a | 127.1 ± 2.6 | 118.3 ± 3.5 | 111.75 ± 3.2 a | 117 ± 3.7 | 0.01 |
a denotes significant relationship compared to HELLP; 1 p value is representative of group effect from two-way ANOVA. Abbreviations: NP (normal pregnant); PreE (preeclampsia); HELLP (hemolysis elevated liver enzyme low platelet); O (Orencia); MAP (mean arterial pressure).