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Neuropathological features of the hippocampus and hypothalamus. Isoprenaline 75 mg/kg at 30 min after challenge. Control rats (a,b). (a) Marked karyopyknosis of pyramidal cells of the hippocampus (black arrows). (b) Rare karyopyknotic cells in hypothalamic area. BPC 157-treated rats (c,d). (c) Small number karyopyknosis of pyramidal cells of the hippocampus. (d) No changes in hipothalamic area. (HE staining; magnification 400×; scale bar 100 μm).
