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. 2022 Feb 10;12:819580. doi: 10.3389/fonc.2022.819580

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Copyright © 2022 Johnson, Uppalapati, Pascual, Estrada, Averitte, Leyva and Hull

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CFH Transcript Number is Increased in Sun-Exposed Skin. GTEx data of 278 paired sun exposed (lower leg) and non-sun exposed (suprapubic) patient samples were analysed. CFH levels are increased in exposed skin (p<0.0001, two-tailed Wilcoxon matched-pairs signed rank test) but not CFI (A, C). Levels of CFH mRNA (TPM) in exposed skin correlates with unexposed skin (p<0.0001, Spearman’s rank-order correlation) (B). When sorted by non-exposed CFH levels, the levels and fold increase in paired exposed samples decreases with the exception being at the highest values of CFH in non-exposed skin (D). (****p<0.0001; ns, not significant).