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. 2022 Feb 10;12:819580. doi: 10.3389/fonc.2022.819580

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Copyright © 2022 Johnson, Uppalapati, Pascual, Estrada, Averitte, Leyva and Hull

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CFH and FH-L Expression in cSCC is Increased. Immunofluorescent microscopy of cells cultured from cSCC tissue show CFH staining (green) in cytosolic vesicles (A). Bands at the expected molecular weight for CFH and Factor H-like (FH-L) are detected in both adjacent normal tissue and cSCC samples (B). The ratio of CFH and FH-L band intensities, normalized to histone H3 intensity, was higher in cSCC tissue compared to ANT [(C), p=0.031 & (D), p=0.034, respectively]. In paired samples for non-invasive cSCC, CFH levels normalized to GAPDH are not significant. When CFH levels in ANT are compared to invasive cSCC, the difference is highly significant [(E), p<0.0001]. (*p<0.05; ***p=0.0001; ****p<0.0001; ns, not significant).