Figure 2.

Transcriptomic characterization of cardiac Ct, ECH, and HF CD64⁺ macrophages. (A) Number of selectively upregulated and downregulated genes in Ct, ECH and HF macrophages. (B) Heat map showing the top genes selectively regulated in ECH (left) and HF (right) macrophages as compared to Ct and HF or Ct and ECH counterparts, respectively (with red and blue indicating increased and decreased expression, respectively). n = 4 mice/group. Normalization and differential statistical analysis were performed with the glm edgeR package. (C) RNAseq analysis. Ingenuity Pathway analysis showing specific canonical pathways and functions statistically enriched in ECH (left) and HF (right) macrophages. Part of the results concerning ECH macrophages specificities were published in Flamant et al.