Table 1.
Summary of the phenotypes of VACV expressing given E3 protein mutants.
| E3 Protein | dsRNA Binding |
PKR Inhibition |
Z-NA Binding |
Necroptosis Inhibition |
Pathogenicity | Reference |
|---|---|---|---|---|---|---|
| wt E3 | yes | yes | yes | yes | high | [16,26,40,72] |
| Δ83N | yes | no | no | no | low | [16,26,40,72] |
| Δ37N | yes | no | no | no | low | [16,26,40,72] |
| Δ73C | no | no | (yes) | yes | (low) | [16] |
| Δ26C | no | no | (yes) | yes | low | [16,72,76] |
| ΔE3L | no | no | (no) | yes | low | [16,26,72,76] |
| P63A | (yes) | yes | no | no | low | [16,75] |
| Y48A | (yes) | yes | no | no | low | [16,75] |
| E42A | (yes) | yes | (yes) | yes | high | [16] |
| mZBP1 Zα | (yes) | (yes) | yes | yes | high | [16,75] |
| hADAR1 Zα | (yes) | (yes) | yes | yes | high | [16,75] |
| hADAR1 Zβ | (yes) | (yes) | no | no | low | [16,75] |
( ) phenotype inferred from available evidence, not tested directly.