Table 3.
Receiver operator characteristic curve analysis to ascertain the optimum cutoff value of major circulating biomarkers at enrollment in order to discern sepsis from septic shock in 102 patients with sepsis.
| Biomarkers | AUC (95% CI) | p-Value | Sensitivity | Specificity | Youden’s Index | Cutoff Value | Positive Predictive Value | Negative Predictive Value |
|---|---|---|---|---|---|---|---|---|
| Chemerin | 0.78 (0.69–0.87) | <0.001 | 71.4% | 70% | 0.41 | 362.8 μg/L | 62.5% | 77.8% |
| CRP | 0.78 (0.68–0.87) | <0.001 | 80% | 69% | 0.49 | 132 mg/L | 64.4% | 83.1% |
| Procalcitonin | 0.71 (0.60–0.81) | 0.001 | 60% | 82.8% | 0.43 | 4.30 μg/L | 70.9% | 74.7% |
| IL-6 | 0.69 (0.58–0.79) | 0.001 | 70% | 62.1% | 0.32 | 24.50 ng/L | 56.4% | 74.7% |
| IL-10 | 0.68 (0.57–0.79) | 0.003 | 60% | 82.8% | 0.43 | 5.88 ng/L | 70.9% | 74.7% |
| suPAR | 0.64 (0.53–0.75) | 0.02 | 75% | 58.6% | 0.34 | 11.79 μg/L | 55.9% | 77% |
Abbreviations: AUC, area under the curve; CI, confidence interval; CRP, C-reactive protein; IL, interleukin; suPAR, soluble urokinase-type plasminogen activator receptor.