Table 1.

Summary of compounds used for ex vivo treatment of T cells.

Drug Class	Compound	T Cell Product	Ref.
Protein kinase inhibitors
mTOR inhibitor	Rapamycin	T cells	[46]
		Anti-EpCAM CAR T cells	[47]
Akt inhibitor	Akt inhibitor VIII	TILs	[48]
			[49]
		Anti-CD19 CAR T cells	[50]
PI3K inhibitor			[51]
	Idelalisib		[52]
			[53]
	Eganelisib	Anti-mesothelin CAR T cells
	Umbralisib
	Duvelisib
	LY294002	Anti-CD33 CAR T cells	[54]
	Idelalisib	CAR T cells	[55]
	Duvelisib
	bb007	Anti-BCMA CAR T cells	[56]
	Duvelisib	Anti-CD5 CAR T cells	[57]
	Idelalisib
BTK inhibitor	Ibrutinib	Anti-CD19 CAR T cells	[58]
Hormone receptor inhibitors
VIP receptor antagonist	VIPhyb	Anti-CD5 CAR T cells	[57]
Epigenetic modulators
	JQ-1	Anti-CD19 CAR T cells	[59]
BET bromodomain inhibitor		Anti-CD33 CAR T cells	[60]
	iBET
Immunomodulatory drugs
Immunomodulator	Lenalidomide	Anti-CS1 CAR T cells	[61]