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(A) (i) Aptamer probe labelled with Cy-3 on the surface of nano-popcorn; (ii) strong Raman signal created by labelled structure. (B) (i) Representation of conformational change that occurred due to recognition of A/H1N1 virus; (ii) effect of recognition on Raman signal. (C) Schematic representation of the SERS-based aptasensor by utilizing a 3D nano-popcorn for the detection of A/H1N1 virus quantitatively (reprinted with permission from [71]. Copyright 2020 Elsevier).
