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(A) The biosynthetic gene cluster (BGC) sequenced and identified from Streptomyces kasugaensis. (B) The proposed biosynthetic pathway of KSM based on the results revealed in this study. KasF is unable to acetylate UDP-GlcNH2 to UDP-GlcNAc. KasQ initiates the KSM biosynthesis by converting UDP-GlcNAc 1 to UDPManNAc 4 through AAG 2 and UDP 3 intermediates. KasH acts as a self-resistance enzyme to acetylate kasugamycin (KSM) to 2-N’-acetyl kasugamycin (Ac-KSM).
