Figure 3.

The tyrosine metabolism regulates the cell cycle. (A) Hierarchical clustering of five tyrosine-metabolizing enzymes transcript levels across HCC tissues in TCGA-LIHC datasets. (B) GSEA pathway enrichment analyses of five tyrosine-metabolizing enzymes’ signature in patients with HCC from the TCGA-LIHC datasets. (C) The core-enriched signaling pathways in high and low tyrosine metabolism groups. NES, normalized enrichment score. (D) The expression of cell cycle-related gene in high and low tyrosine metabolism groups. The p values were determined by the two-tailed t-tests. *** p < 0.001.