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. 2022 Feb 15;14(4):979. doi: 10.3390/cancers14040979

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The distribution of human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) levels are plotted for 77 cases with accessible laboratory data as well as tissue diagnosis from a resection specimen. The red line indicates the criteria in COG ACNS 1123, and the blue line indicates that in SIOP CNS GCT II. No single line completely segregates germ cell tumor (GCT) cases without malignant components. TM: tumor marker, G: germinoma, MT: mature teratoma, ImT: immature teratoma, NGGCT: non-germinomatous GCT.