Table 1.
Clinical characteristics and follow-ups of 17 cases with positive tumor markers and no malignant non-germinomatous histopathological component, obtained from large resection specimens.
| Histopathological Diagnosis | Tumor Location | Age (Years) | Sex | Serum Total HCG (IU/L) | CSF Total HCG (IU/L) | Serum AFP (ng/mL) | CSF AFP (ng/mL) | EOR | Chemotherapy | Radiation Therapy | Recurrence | Alive or Dead | F/U (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ImT | Ventricle | 0 | F | 10,481 | STR | None | None | No | Dead | 0 | |||
| ImT | Frontal lobe | 0 | F | 2.7 | 224,865 | PR | None | None | No | Dead | 0 | ||
| G | Neurohypophysis + ventricle | 24 | M | 3267.5 | 1.3 | 0.8 | STR | None | None | No | Dead | 0 | |
| ImT | Basal ganglia | 13 | M | 126.2 | 66.9 | GTR | PE | WBI + local | No | Alive | 4 | ||
| ImT + G | Pineal | 11 | M | 0.1 | 0.1 | 372.8 | 20.2 | GTR | PE | WVI + local | No | Alive | 5 |
| ImT | Pineal | 16 | M | 0.1 | 32.4 | 192.2 | 568.59 | GTR | PE, ICE, VP16, VBL, TIP | WBI + local | Yes | Dead | 5 |
| ImT + G | Pineal | 16 | M | 64 | 74.5 | STR | CARE | WVI | Yes | Dead | 12 | ||
| G | Pineal | 25 | M | 13.4 | 31 | STR | No data | No data | No | Alive | 22 | ||
| ImT | Pineal | 11 | M | 0.1 | 0.1 | 80.7 | 1.06 | STR | PE | WBI + local | No | Dead | 33 |
| ImT | Pineal | 4 | M | 17.2 | 0.1 | GTR | PE | WVI + local | No | Alive | 40 | ||
| ImT | Pineal | 10 | M | 0.1 | 7.49 | 97 | 41.76 | GTR | PE | WBI + local | No | Alive | 61 |
| G | Temporal lobe | 16 | M | 105.6 | 2.6 | STR | PE | WBI | No | Alive | 63 | ||
| ImT | Pineal | 0 | M | 9359 | 6.9 | GTR | ICE | CSI + local | No | Alive | 86 | ||
| G + MT | Pineal | 14 | M | 18 | 1441 | 2.2 | 64 | STR | ICE | CSI + local | No | Alive | 87 |
| G | Pineal | 17 | M | 32 | 58 | 1.1 | 0.1 | STR | PE | CSI + local | No | Alive | 141 |
| G | Pineal | 4 | M | 0.8 | 85 | GTR | PE | WVI | No | Alive | 196 | ||
| MT + ImT + G | Pineal | 12 | M | 0.1 | 0.1 | 12.4 | 0.1 | GTR | PE | No data | No | Alive | 227 |
Abbreviations: CSF; cerebrospinal fluid, EOR; extent of resection, F/U; follow-up, G; germinoma, MT; mature teratoma, ImT; immature teratoma, M; male, F; female, GTR; gross total resection, STR; subtotal resection, PR; partial resection, PE; cisplatin + etoposide, ICE; ifosfamide + cisplatin + etoposide, VBL; vinblastine, TIP; paclitaxel + ifosfamide + cisplatin, CARE; carboplatin + etoposide, WBI; whole-brain irradiation, WVI; whole-ventricular irradiation, CSI; craniospinal irradiation, local; local irradiation.