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. 2022 Feb 20;11(4):736. doi: 10.3390/cells11040736

Figure 2.

Figure 2

Exogenously administered Shh does not lead to significant changes in the survival of NPCs under normal (Control vs. Shh only; p = 0.1532) and inflammatory (LPS only vs. Shh+LPS; p > 0.9999) growing conditions in the CCK-8 viable cell quantification after 24 h. However, blockage of the Shh-pathway via administration of Cyclopamine decreases NPC-survival under normal (Control vs. Cyclo only; p = 0.0007) and inflammatory (LPS only vs. Cyclo+LPS: p < 0.001 and Cyclo+LPS vs. Shh+LPS; p < 0.001) growing conditions. Experiments performed in triplicate (n = 3), data expressed in percentage of the control group and presented as mean ± SEM, one-way-ANOVAs with post hoc Tukey-HSD tests performed for statistical analysis (* p < 0.05; *** p < 0.001).