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Biogenesis and function of circRNAs. CircRNAs were generated by back splicing of precursor mRNAs, and they can be classified as exonic circRNAs (ecircRNAs), exon-intron circRNAs (EIciRNAs), and circular intronic RNAs (ciRNAs) based on the introns or exons it contains. Typically, circRNAs sponge micro RNAs and rescue their repression of downstream mRNAs. RISC: RNA-induced silencing complex.
