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. 2022 Feb 15;14(4):956. doi: 10.3390/cancers14040956

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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BRAF-MEK-ERK signaling pathway in classic hairy cell leukemia and targets for therapeutic intervention. ERK-dependent negative feedback abrogates RTK-mediated RAS activation, making BRAF V600E a functional monomer.