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. 2022 Feb 9;11(4):603. doi: 10.3390/cells11040603

Figure 7.

Figure 7

Actin is involved in postsynaptic receptor localization and trafficking. (A): The intracellular tails of GluN2B subunits interact with Nck2 to stimulate actin nucleation via N-WASp and the Arp2/3 complex. (B): Actin filaments anchor and space out glycine receptors. Disruption of actin filaments leads to smaller, denser clusters of glycine receptors and increases their diffusion out of synaptic zones. (C): Myo6 traffics AMPARs away from the PSD through actin filaments. Adapted from “Axonal-dendritic synaptic cleft, Dendritic spine, Post-synaptic membrane and Pre-synaptic membrane”, by https://BioRender.com (accessed on 26 January 2022) (2020). Created and retrieved from https://app.biorender.com/biorender-templates (accessed on 26 January 2022).