Table 4.

Human study in substance use disorder.

	Aim and Study Design	Number of Participants	Population	Lamotrigine Dose and Root	Ketamine Dose and Root		Outcome
Maheshwari et al. 2021 [52]	To test the hypothesis that a single dose of lamotrigine 300-mg given before surgery reduces ketamine-induced psychological disturbances. Pilot randomized double-blind trial Relative risk (95% CI)	46 adults (23 Lamotrigine, 23 placebo)	Patients scheduled for elective noncardiac surgery with general anesthesia	Lamotrigine 300 mg/d Single dose	ketamine 1 mg/kg bolus at induction of anesthesia followed by a 5-μg/kg/min infusion which was stopped at the end of surgery.	BPRS	No patients randomized to lamotrigine had psychologic disturbances measured with BPRS, whereas 3 (14%) assigned to placebo did.

TRD = treatment resistant depression; TRBD = treatment resistant bipolar depression; 16 item Self-Report Quick Inventory of Depressive Symptomatology (QIDS-SR16); Beck Depression Inventory (BDI).