Table 5.

Human studies in anesthesia.

Author	Aim and Study Design	Numer of Subjects	Population	Lamotrigine Dose and Root	Ketamine Dose and Root	Tests and Measures	Outcomes
Chan et al. 2018 [53]	Case series	13 TRD and TRBD patients, 2 of them (TRBD) received ketamine and lamotrigine		Patient 1 Lamotrigine 200 mg/d oraly Patient 2 Lamotrigine 200 mg/d oraly	Patient 1 Ketamine 0.5 mg/kg iv 42 infusions over 7 months Patient 2 Ketamine 0.5 mg/kg iv Single infusion	QIDS-SR16 BDI	Patient 1 Mood, suicidality and cognitive functions improved Patient 2 Active suicidal ideation resolved 24 h after ketamine infusion
Huang et al. 2016 [54]	Case report	1	25 years old male with ketamine use disorder	Lamotrigine 100 mg/d orally (slow titration)	He used ketamine 6–10 times almost daily (total, 4–5 g/day) by smokind and snorting	Not stated	one case of ketamine use disorder who experienced a great reduction in craving and ketamine use after lamotrigine treatment
Kornhal and Nielsen 2014 [55]	Case report describing Failure of Ketamine Anesthesia in a patient with lamotrigine overdose	1 bipolar patient	-	Lamotrigine intoxication, serum concentration was 191.9 micromol/Ltherapeutic reference area is 10–60 micromol/L.	total ketamine dose of 250 mg iv	Not stated	Despite being injected with a total of 250 mg ketamine, The patient presented no signs of dissociative anaesthesia.

TRD = treatment resistant depression; TRBD = treatment resistant bipolar depression; 16 item Self-Report Quick Inventory of Depressive Symptomatology (QIDS-SR16); Beck Depression Inventory (BDI).