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. 2022 Feb 20;14(4):1071. doi: 10.3390/cancers14041071

Figure 3.

Figure 3

ADCK2 inhibits the migration and invasion of SkMel28 cells. (A) Knockdown of ADCK2 led to a faster migration of SkMel28 cells compared to control cells. A significantly faster migration was measured 22 h and 26 h after transfection with siRNAs (n = 4). (B): ADCK2 overexpression SkMel28 cells migrate slower than EV control cells (n = 4). (C): Knockdown of ADCK2 in SkMel28 cells leads to a higher invasion capacity through a BME-coated matrix compared to siControl-transfected cells (n = 4). (D): SkMel28 OE ADCK2 cells show a lower invasion capacity through a BME-coated matrix compared to SkMel28 EV control cells (n = 4). All statistical analyses were conducted with paired t-test. * p ≤ 0.05; ** p ≤ 0.01.