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. 2022 Feb 14;11(4):654. doi: 10.3390/cells11040654

Figure 5.

Figure 5

RKIP-mediated GRK2 inhibition leads to sensitisation of the heart failure-promoting AGTR1 and cardiac fibrosis. (a) Schematic illustration of the RKIP-mediated pathway leading to cardiac fibrosis. (b) Heat map of the relative cardiac transcript levels of fibrosis-related Agtr1a (angiotensin II receptor type 1a), Ace (angiotensin-converting enzyme), Tgfb1 (transforming growth factor beta 1), Col1a1 and Col1a2 (collagen type I alpha 1 and 2 chain), Col3a1 (collagen type III alpha 1 chain), Ccn2 (cellular communication network factor 2) and Fn1 (fibronectin 1) of Tg-RKIP mice and FVB controls (n = 3). (c) Cardiac fibrosis in 8-month-old male Tg-RKIP mice (upper panels) was detected by picrosirius red staining of cardiac specimens and compared to age-matched, non-transgenic FVB mice (lower panels), which were used as controls (n = 4 hearts per group; bar: 40 μm). Data come from our published studies of Tg-RKIP mice with FVB background [11,22]. NGS data are available at the NCBI GEO database, accession number GSE191316. The heat map was generated by Morpheus, https://software.broadinstitute.org/morpheus (accessed on 26 December 2021).