Skip to main content
. 2022 Feb 17;11(4):710. doi: 10.3390/cells11040710

Figure 2.

Figure 2

The effect of aging and exercise on NAD+ homeostatic regulation in muscle. Aging increases the demand on NAD+ due to the activation of SIRTs, PARP-1, and CD38. Decreased NAD+ content reduces SIRT1 activity, which plays a key role in mitigating protein acetylation and maintaining mitochondrial homeostasis during aging. NAD+ levels may be partially restored by higher NAMPT activity and by supplementation of NAD+ precursors. For abbreviations, see the list at the end of the paper. Figure created with BioRender.com.