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All images represent staining with hematoxylin-eosin (H&E) unless otherwise specified. (A) Low-power image of a pheochromocytoma (star) arising in adrenal gland asterisk). (B) High-power view illustrating the classical nested appearance of the tumor cells with a finely granular, amphophilic cytoplasm. (C) Subsets of cases may display nuclear pleomorphism and hyperchromatic nuclei. (D) Immunohistochemistry reveals diffuse chromogranin A positivity.
