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. 2022 Feb 10;14(4):876. doi: 10.3390/cancers14040876

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The mechanisms of roles of selected miRNAs involved in parathyroid tumorigenesis. (A). MiR-296 negatively correlates with HGS mRNA expression levels. HGS overexpression leads to tumor cell invasiveness and metastasis according to the downregulation of E-cadherin. (B). MiR-222 inhibits CDKN1B/p27Kip1 involved in cell cycle regulation. (C). The downregulation of miR-126-5p induces angiogenesis via VEGF. (D). MiR-372 inhibits CDKN1A/p21 genes and decreases parathyroid cells’ sensitivity to apoptosis. Created with BioRender.com (accessed on 1 February 2022).