Figure 2.

Effects of imipramine (IMP) on hypoglycemia-induced hippocampal neuronal death. Hypoglycemia resulted in hippocampal neuronal death in the subiculum (subi), CA1, and DG regions. (A) Fluoro-Jade B (FJB)-positive neuronal cells, degenerating cells, were observed in the subi, CA1, and DG regions after hypoglycemia. Scale bar = 50 µm. (B) The number of FJB (+) cells was greatly lower in the imipramine-treated group than in the vehicle group after insult. Data are the mean ± SEM; n = 9–10 from each hypoglycemia group. Individual data points (▲ = HG-Veh, ▼ = HG-IMP). * Significantly different from the vehicle-treated group at p < 0.05.