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. 2022 Feb 14;11(4):667. doi: 10.3390/cells11040667

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Administration of imipramine improved neurologic and cognitive function after hypoglycemia: (A) the mNSS was scored in rats at 1, 4, 7, and 14 days after hypoglycemia. A score of 18 indicated that all trials had failed; a score of 0 indicated that all trials were completed. (B) ART performance test for 1 week: the imipramine-treated group removed the tape faster than the vehicle-treated group after hypoglycemia. (C–E) The MWM performance test. (C) The target platform arrival time for 5 consecutive days starting post-injury day (PID) 9. (D) The distance to target: the imipramine-treated group had a shorter distance to reach the target over time than the vehicle-treated group. (E) The average tracking record of each group reaching the target. Data are the mean ± SEM; n = 3 for each sham group. n = 5–7 for each hypoglycemia group. * Significantly different from the vehicle-treated group at p < 0.05, # significantly different from the sham-operated group at p < 0.05.