Table 3.
The inhibited concentrations (IC50, μM) for HepG2, Caco-2 and Balb/c 3T3 cells exposed to [Ag(MTZ)2]2SO4, [Ag(MTZ)2NO3], Ag2SO4, AgNO3, MTZ and cisplatin for 72 h determined by the MTT, NRU, TPC and LDH assays. Data are presented as mean ± SD, n = 3.
| HepG2 | Caco-2 | Balb/c 3T3 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MTT | NRU | TPC | LDH | MTT | NRU | TPC | LDH | MTT | NRU | TPC | LDH | |
| [Ag(MTZ)2]2SO4 | 2.88 a ± 0.3 |
2.93 a ± 0.3 |
3.13 a ± 0.1 |
3.02 a ± 0.1 |
2.73 a ± 0.3 |
2.63 a ± 0.4 |
3.05 a ± 0.1 |
2.61 a ± 0.6 |
4.17 b ± 0.1 |
4.06 b ± 0.1 |
4.29 b ± 0.3 |
4.53 b ± 0.2 |
| [Ag(MTZ)2NO3] | 8.03 a ± 0.5 |
8.24 a ± 0.3 |
>10 | 4.45 a ± 0.3 |
7.32 a ± 0.4 |
6.96 a ± 0.4 |
8.62 a ± 0.5 |
4.42 a ± 0.4 |
2.42 b ± 0.6 |
2.17 b ± 0.2 |
2.04 b ± 0.4 |
4.21 a ± 0.5 |
| Ag2SO4 | >10 | >10 | >10 | 3.13 a ± 0.2 |
9.01 a ± 0.5 |
7.23 a ± 0.2 |
8.23 a ± 0.5 |
7.42 b ± 0.03 |
1.92 b ± 0.2 |
2.57 b ± 0.3 |
2.39 b ± 0.4 |
2.56 c ± 0.2 |
| AgNO3 | 5.50 a ± 0.3 |
5.06 a ± 0.2 |
>10 | 3.06 a ± 0.3 |
5.40 a ± 0.6 |
3.85 a ± 0.4 |
5.49 a ± 0.5 |
3.20 a ± 0.2 |
2.72 b ± 0.2 |
2.82 b ± 0.3 |
2.92 b ± 0.04 |
3.60 a ± 0.3 |
| MTZ | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| Cisplatin | 3.6 a ± 1.3 |
5.20 a ± 0.4 |
2.00 a ± 0.8 |
<0.1 | 9.12 b ± 0.8 |
3.30 b ± 0.2 |
5.30 b ± 0.5 |
>10 | >10 | >10 | >10 | >10 |
The different letters (a, b, c) within lines indicate significant differences (p ≤ 0.05) between the cell cultures for the corresponding assay; <0.01—the IC50 value was under 0.01 µM (the lowest concentration tested); >10—the IC50 value was over 10 µM (the highest concentration tested).