Table 4.
Antimicrobial activity defined as minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of silver(I) complexes and reference compounds—metronidazole (MTZ) and silver sulfadiazine (Ag sulfadiazine).
| Chemicals | MTZ | [Ag(MTZ)2]2SO4·5H2O | Ag2SO4 | [Ag(MTZ)2 NO3] | AgNO3 | Ag sulfadiazine | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| in mg/L (µM/mL) | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | ||
| Microorganism | ||||||||||||||
| Gram-positive bacteria | Aerobic |
S. aureus
ATCC 25923 |
>1000
(>5.85) |
>1000
(>5.85) |
15.6
(0.014) |
15.6
(0.014) |
15.6
(0.05) |
31.3
(0.1) |
15.6
(0.049) |
62.5
(0.2) |
7.8
(0.049) |
31.3
(0.185) |
7.8
(0.022) |
15.6
(0.044) |
|
S. epidermidis
ATCC 12228 |
500
(2.93) |
500
(2.93) |
7.8
(0.007) |
15.6
(0.014) |
15.6
(0.05) |
31.3
(0.1) |
7.8
(0.025) |
62.5
(0.2) |
3.9
(0.025) |
15.6
(0.09) |
15.6
(0.044) |
15.6
(0.044) |
||
|
M. luteus
ATCC 10240 |
1000
(5.85) |
>1000
(>5.85) |
7.8
(0.007) |
125
(0.12) |
15.6
(0.05) |
125
(0.4) |
7.8
(0.025) |
62.5
(0.2) |
3.9
(0.025) |
31.3
(0.185) |
3.9
(0.011) |
31.3
(0.088) |
||
|
B. subtilis
ATCC 6633 |
125
(0.73) |
250
(1.46) |
15.6
(0.014) |
15.6
(0.014) |
31.3
(0.1) |
31.3
(0.1) |
15.6
(0.049) |
15.6
(0.049) |
15.6
(0.09) |
15.6
(0.09) |
3.9
(0.011) |
7.8
(0.022) |
||
|
B. cereus
ATCC 10876 |
500
(2.93) |
>1000
(>5.85) |
62.5
(0.06) |
125
(0.12) |
31.3
(0.1) |
500
(1.6) |
62.5
(0.2) |
125
(0.4) |
31.3
(0.185) |
62.5
(0.37) |
15.6
(0.044) |
125
(0.352) |
||
|
E. faecalis
ATCC 29212 |
>1000
(>5.85) |
>1000
(>5.85) |
31.3
(0.03) |
62.5
(0.06) |
31.3
(0.1) |
125
(0.4) |
31.3
(0.1) |
62.5
(0.2) |
15.6
(0.09) |
31.3
(0.185) |
31.3
(0.088) |
31.3
(0.088) |
||
| Anaerobic |
A. israeli
ATCC 10049 |
>1000
(>5.85) |
>1000
(>5.85) |
7.8
(0.007) |
15.6
(0.014) |
0.98
(0.003) |
15.6
(0.05) |
0.49
(0.0015) |
3.9
(0.012) |
0.49
(0.003) |
0.49
(0.003) |
62.5
(0.176) |
125
(0.352) |
|
|
P. acnes
ATCC 11827 |
>1000
(>5.85) |
>1000
(>5.85) |
125
(0.12) |
500
(0.46) |
125
(0.4) |
500
(1.6) |
125
(0.4) |
125
(0.4) |
62.5
(0.37) |
62.5
(0.37) |
125
(0.352) |
500
(1.408) |
||
|
C. perfringens
ATCC 13124 |
1.95
(0.01) |
1.95
(0.01) |
1.95
(0.002) |
3.9
(0.004) |
250
(0.8) |
250
(0.8) |
1.95
(0.006) |
1.95
(0.006) |
62.5
(0.37) |
62.5
(0.37) |
31.3
(0.088) |
250
(0.704) |
||
| Gram-negative bacteria | Microaerophilic/Aerobic |
C. jejunii
ATCC 33291 |
500
(2.93) |
>1000
(>5.85) |
250
(0.23) |
500
(0.46) |
1000
(3.2) |
>1000
(>3.2) |
31.3
(0.1) |
125
(0.4) |
62.5
(0.37) |
125
(0.74) |
62.5
(0.176) |
62.5
(0.176) |
|
H. pylori
ATCC 43504 |
15.6
(0.09) |
15.6
(0.09) |
7.8
(0.008) |
31.3
(0.03) |
15.6
(0.05) |
15.6
(0.05) |
15.6
(0.049) |
15.6
(0.049) |
15.6
(0.09) |
15.6
(0.09) |
31.3
(0.088) |
31.3
(0.088) |
||
|
S. typhimurium
ATCC 14028 |
>1000
(>5.85) |
>1000
(>5.85) |
15.6
(0.014) |
62.5
(0.06) |
31.3
(0.1) |
250
(0.8) |
15.6
(0.049) |
31.3
(0.1) |
15.6
(0.09) |
15.6
(0.09) |
15.6
(0.044) |
31.3
(0.088) |
||
|
E. coli
ATCC 25922 |
>1000
(>5.85) |
>1000
(>5.85) |
15.6
(0.014) |
31.3
(0.03) |
62.5
(0.2) |
62.5
(0.2) |
15.6
(0.049) |
31.3
(0.1) |
7.8
(0.049) |
15.6
(0.09) |
15.6
(0.044) |
31.3
(0.088) |
||
|
P. mirabilis
ATCC 12453 |
>1000
(>5.85) |
>1000
(>5.85) |
15.6
(0.014) |
15.6
(0.014) |
31.3
(0.1) |
31.3
(0.1) |
15.6
(0.049) |
31.3
(0.1) |
7.8
(0.049) |
15.6
(0.09) |
7.8
(0.022) |
15.6
(0.044) |
||
|
K. pneumoniae
ATCC 13883 |
1000
(5.85) |
1000
(5.85) |
15.6
(0.014) |
31.3
(0.03) |
31.3
(0.1) |
31.3
(0.1) |
15.6
(0.049) |
31.3
(0.1) |
7.8
(0.049) |
7.8
(0.049) |
15.6
(0.044) |
31.3
(0.088) |
||
|
P. aeruginosa
ATCC 9027 |
>1000
(>5.85) |
>1000
(>5.85) |
7.8
(0.008) |
15.6
(0.014) |
62.5
(0.2) |
125
(0.4) |
7.8
(0.025) |
15.6
(0.049) |
3.9
(0.025) |
3.9
(0.025) |
7.8
(0.022) |
15.6
(0.044) |
||
| Anaerobic |
B. fragilis
ATCC 10240 |
0.49
(0.003) |
0.49
(0.003) |
0.24
(0.0002) |
0.98
(0.0009) |
250
(0.8) |
1000
(3.2) |
0.98
(0.003) |
0.98
(0.003) |
15.6
(0.09) |
62.5
(0.37) |
15.6
(0.044) |
62.5
(0.176) |
|
|
P. intermedia
ATCC 25611 |
1000
(5.85) |
>1000
(>5.85) |
0.98
(0.0009) |
15.6
(0.014) |
7.8
(0.025) |
7.8
(0.025) |
0.98
(0.003) |
0.98
(0.003) |
0.49
(0.003) |
0.49
(0.003) |
3.9
(0.011) |
31.3
(0.088) |
||
|
F. nucleatum
ATCC 25586 |
1.95
(0.01) |
1.95
(0.01) |
0.49
(0.0004) |
0.49
(0.0004) |
31.3
(0.1) |
31.3
(0.1) |
0.49
(0.0015) |
0.98
(0.003) |
0.49
(0.003) |
0.98
(0.006) |
3.9
(0.011) |
15.6
(0.044) |
||
|
V. parvula
ATCC 10790 |
1.95
(0.01) |
1.95
(0.01) |
3.9
(0.004) |
3.9
(0.004) |
62.5
(0.2) |
62.5
(0.2) |
1.95
(0.006) |
1.95
(0.006) |
7.8
(0.049) |
15.6
(0.09) |
3.9
(0.011) |
31.3
(0.088) |
||