Table 2.
Location of CB1 and CB2 Receptors (adapted from [9]).
| CB1 Receptors | CB2 Receptors |
|---|---|
|
Abundant in the Central Nervous System: Brain nerves/neurons in particular; also present in cerebral blood vessels; also to some extent in microglia, astrocytes; spinal cord Also present in: Peripheral Nervous System: sympathetic nerve terminals, trigeminal ganglion, dorsal root ganglion, dermic endings of primary sensory neurons; neurons of parasympathetic nervous system Blood, Tissues, Immune Cells: adipose tissue (white, brown), connective tissue, fascia, fibroblasts, skeletal muscle, bone (osteoclasts, osteoblasts); smooth muscle (vascular and visceral); blood vessels, vascular endothelial cells, blood (leukocytes), vascular smooth muscle cells; immune cells including macrophages, mast cells Organs & Glands: skin, GI tract, eye, liver, heart, kidney, bladder, adrenal gland, spleen, tonsils. lung, endocrine glands (e.g., thyroid, adrenals, pituitary gland), exocrine glands, reproductive organs: male (testes) and female (uterus, ovaries), placenta |
Highly Concentrated in Cells/Tissues/Organs of Immune System: Monocytes, macrophages, CD4+ and CD8+ T Cells, B-cells, NK cells, neutrophils, mast cells; spleen, tonsils, thymus Also present in: CNS (present in lower levels in CNS): cell bodies and dendrites of central neurons; cortex, brainstem, cerebellum, striatum, hippocampus, amygdala, retina, neuronal, glial (astrocytes, microglia) and endothelial cells of brain; Spinal Cord and Dorsal Root Ganglia Blood, Tissues, Cells: various human tumours, adipocytes, leucocytes, bone marrow; bone (osteoclasts, osteoblasts, osteocytes), muscle cells, human vascular smooth muscle, endothelial cells Organs: skin, GI tract, liver, heart, pancreas, spleen, lung, kidneys, bladder, reproductive organs & cells (e.g., ovary); placenta |