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Poorer OS in mesothelioma is correlated with elevated LOX/LOXL mRNA levels. A combined gene expression of LOX, LOXL1, LOXL2, LOX3 & LOXL4 (5 signatures group) was analyzed for OS using the TCGA MESO dataset in Gepia2 [159], and stratified at the median between high expression and lox expression. When stratified at the median, the high 5 signatures group had a significantly worse OS (p = 3.6 × 10−6).
