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The potential mechanisms of TM6SF2 in hepatic lipid metabolism. TM6SF2 localized to ER and ERGIC. (Adapted from Mahdessian et al., Proc Natl Acad Sci U S A 2014;111:8913‐8918.). TM6SF2 interacts with APOB and is involved in the second lipidation of VLDLs. Abbreviations: COP II, coat protein complex II; ERAD, endoplasmic‐reticulum‐associated protein degradation.
