TABLE 3.
Multivariable Analysis for LD
| Parameter | Univariate Analysis | Multivariable Analysis sAxl | Multivariable Analysis Gas6 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P Value | OR | 95% CI | P Value | OR | 95% CI | P Value | |
| sAxl (ng/mL) | 1.049 | 1.013‐1.086 | 0.007 | 1.056 | 1.017‐1.096 | 0.005 | — | — | — |
| Gas6 (ng/mL) | 1.049 | 1.012‐1.088 | 0.010 | — | — | — | 1.062 | 1.020‐‐1.106 | 0.004 |
| Gender | 0.974 | 0.340‐2.794 | 0.961 | ||||||
| Neoplastic entity | 1.263 | 0.816‐1.955 | 0.294 | ||||||
| Hepatic resection | 6.154 | 1.352‐28.011 | 0.019 | 6.423 | 1.307‐31.576 | 0.022 | 7.580 | 1.428‐40.233 | 0.017 |
| Co‐factors | |||||||||
| Cirrhosis | 1.937 | 0.555‐6.761 | 0.300 | ||||||
| Fibrosis (≥ III) | 1.545 | 0.491‐4.868 | 0.457 | ||||||
| CASH | 0.429 | 0.089‐2.078 | 0.293 | ||||||
| SOS | 0.715 | 0.085‐6.056 | 0.759 | ||||||
| Steatosis (%) | 1.007 | 0.986‐1.028 | 0.545 | ||||||
| Preoperative parameters | |||||||||
| Platelets (×103/µL) | 0.997 | 0.990‐1.005 | 0.450 | ||||||
| Bilirubin (mg/dL) | 1.816 | 0.984‐3.351 | 0.056 | ||||||
| PT (%) | 0.994 | 0.969‐1.020 | 0.632 | ||||||
| ALP (U/L) | 1.006 | 1.001‐1.011 | 0.016 | 0.999 | 0.990‐1.008 | 0.824 | 0.998 | 0.990‐1.007 | 0.704 |
| GGT (U/L) | 1.002 | 1.000‐1.004 | 0.030 | 1.000 | 0.996‐1.004 | 0.972 | 1.000 | 0.996‐1.004 | 0.957 |
| AST (U/L) | 1.015 | 1.003‐1.027 | 0.013 | 0.999 | 0.982‐1.015 | 0.880 | 0.999 | 0.982‐1.017 | 0.940 |
| ALT (U/L) | 1.004 | 0.995‐1.012 | 0.417 | ||||||
| Albumin (g/L) | 0.864 | 0.758‐0.986 | 0.031 | 0.896 | 0.765‐1.050 | 0.175 | 0.921 | 0.786‐1.080 | 0.311 |
| Age (years) | 1.024 | 0.982‐1.067 | 0.268 | ||||||
Statistically significant values are shown in bold.
Abbreviations: 95% CI, 95% confidence interval; ALP, alkaline phosphatase; ALT, alanine aminotransferasase; AST, aspartate aminotransferase; CASH, chemotherapy associated steatohepatitis; GGT, gamma‐glutamyl transpeptidase; OR, odds ratio; PT, prothrombin time; SOS, sinusoidal obstruction syndrome.